Figure 1.
How the CTLA-4 inhibitor works. Anti-CTLA-4 therapy blocks inhibitory signals to cytotoxic (CD8+) and helper (Th1 and Th2) T lymphocytes and suppresses the activation of regulatory T cells (CD4/25+). (Reprinted from Kroll et al1 with permission.)

How the CTLA-4 inhibitor works. Anti-CTLA-4 therapy blocks inhibitory signals to cytotoxic (CD8+) and helper (Th1 and Th2) T lymphocytes and suppresses the activation of regulatory T cells (CD4/25+). (Reprinted from Kroll et al1  with permission.)

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