When to consider telomere length measurements in adults. *Includes unexplained, persistent cytopenia, aplastic anemia. †Consider chromosome breakage testing to exclude Fanconi anemia. ‡Includes liver cirrhosis, fibrosis, hepatopulmonary syndrome, idiopathic portal hypertension. ^§Mucocutaneous triad consisting of leukoplakia, reticular skin pigmentation, and nail dysplasia. FH, family history; HPV, human papilloma virus.