Automated exchange compared to manual and simple blood transfusion attenuates rise in ferritin level after 1 year of regular blood transfusion therapy in chronically transfused children with sickle cell disease.²⁶  Change in ferritin levels in participants of the Silent Cerebral Infarct Trial (n  =  83) randomized to transfusions. The median (IQR) ferritin levels after 1 year of transfusion were as follows: 1800  ng/mL (IQR, 1426 to 2204  ng/mL) in simple transfusion participants, 1530  ng/mL (IQR, 1205 to 1805  ng/mL) in manual exchange participants, and 355  ng/mL (IQR, 179 to 579  ng/mL) in automated RBC exchange participants. Figure reprinted from Kelly et al.²⁶