VWF multimer distribution in children with SCD treated with hydroxycarbamide compared to blood transfusion. (A) Representative images of VWF multimer distribution in HC and BT cohorts. Percentage of (B) high-, (C) intermediate-, and (D) low-molecular-weight VWF multimers. Comparisons between groups were assessed by the Mann-Whitney U test. Dotted red lines represent the percentage of high-, intermediate-, and low-molecular-weight multimers in normal pooled plasma (NPP); ∗P < .05, ∗∗∗P < .001, and ∗∗∗∗P < .0001.