TFBM analyses. Bioinformatic analyses quantified ratio of upregulated vs downregulated TFBMs within these 4 PRO domains. There was a pattern of increased activation of inflammation-related TFBMs (NF-κB and AP-1) with decreased patient-reported well-being, with the most pronounced difference in the social well-being domain. Differences in myeloid lineage TFBMs (MEIS1-3) were observed, consistent with CTRA immunobiology as previously described. PWB, physical well-being; SWB, social well-being.