Gene expression and transcription factor activity in MLL-EDC4 compared with other MLL-r cases. (A) Enriched gene sets in upregulated and downregulated genes of MLL-EDC4 AML cells compared with all other AML cells visualized as dot plots. Gene sets from the Hallmark, Reactome, and Gene Ontology Biological Processes (GO:BP) databases were used. (B) Clustered single-cell transcriptomic heat map of the most differentially expressed genes between AML cell clusters. (C) Heat map of transcription factor activities for AML cells based on scRNA-seq data. (D) Transcription factor network colored by transcription factor activity.