RNA-seq reveals gene expression changes in LIC after exposure to Poly(A:U). (A) GSEA showing upregulated (top) and downregulated (bottom) pathways in LICs from Poly(A:U)-treated young Eμ -Ret mice compared with those in LICs from untreated littermates. (B) Enrichment plot of genes in significantly altered hallmark pathways gene sets. (C) Plasma cytokine levels measured 16 hours after PBS or Poly(A:U) administration to Eμ-Ret neonates and adults (n = 3 mice per group). MCP-1, (Monocyte Chemoattractant Protein-1).