Genetic score of PR and its association with health outcomes. (A) A scatterplot, each dot of which corresponds to a variant identified by stepwise multiple regression analysis of genetic associations with PPR in INTERVAL. The x-axis shows the estimated additive effect size of each variant on mean PPR in INTERVAL. The y-axis shows the estimated additive effect size of each variant on the mean of the agonist-specific PR phenotype with the smallest P value in the PFC. The 2 sets of effect sizes were scaled in order to render them commensurable, as described in “Methods.” (B) Histogram of the genetic score for PR after adjusting for known risk factors and platelet traits computed in UK Biobank participants, with participants in the upper and lower vigintiles of the distribution marked in red and blue, respectively. (C-D) Kaplan-Meier plots corresponding to the 2 vigintile subgroups for the 2 health outcomes significantly associated with the genetic score. Plain lines indicate the estimated survival functions and the shaded areas represent the 90% confidence intervals. (E-G) Funnel plots showing estimates of the log odds ratios for a disease event per standard deviation increase in PPR. The horizontal line segments represent the corresponding 95% confidence intervals. The black circle and line segment lying on the line y = 0 show the estimate and 95% confidence interval for the log odds ratio derived from an IVW fixed-effects meta-analysis. The confidence intervals were derived using second-order weights. Each point is colored according to the PR phenotype used to calculate the general PR effect size of the corresponding variant.