Genome-wide associations with PPR. A Manhattan plot showing the P values of linear mixed model tests for association between genetic variants and PR predicted from CBC scattergrams in INTERVAL. Each dot corresponds to a genetic variant in the Haplotype Reference Consortium r1.1 reference panel. The position on the x-axis indicates the physical position of the variant; the position on the y-axis indicates the log of –log₁₀ of the P value corresponding to the χ²_BOLT-LMM statistic. Only variants with an imputation information score >0.4 and a P value <.1 are shown. The horizontal dashed line corresponds to the genome-wide significance threshold (α = 10^–8). The red dots correspond to the variants showing the strongest evidence for association in loci containing significantly associated variants. The gene names indicate the protein-coding gene that is nearest to each of these associated variants. The genes in bold mark loci previously associated with a PR phenotype by GWAS analysis (P < 5 × 10^–8) or by gene-based analysis (P < 10^–5; marked with an asterisk).