Splenic iron concentration decreased in subjects with high levels at baseline, and the change in the splenic iron content is highly correlated with initial splenic iron content. (A) Splenic iron concentration as a function of drug exposure. Time zero represents the time of drug initiation. Patients with clinically relevant spleen iron concentration exhibited marked improvements. Only 1 patient had significantly increased spleen iron content. (B) Reductions in spleen iron content as a function of the initial spleen iron content. The patient with the highest initial spleen iron content was excluded because their spleen iron change could be attributed to a marked change in chelator compliance (LIC dropped by ∼40 mg/g over the study interval). After doing so, Δ spleen iron content was independent of Δliver iron content (r² = 0.007; P = .78).