Cumulative incidence of SARS-CoV-2 infection in fully boosted patients with MM or MGUS, and controls. Cumulative incidence curves of breakthrough SARS-COV-2 infection by disease state (MM, MGUS, and their matched controls) are shown, with time 0 set as 14 days after the day of third dose of vaccination. Confidence intervals were calculated by bootstrapping. The number at risk are also shown. The inset tables show HRs for SARS-CoV-2 breakthrough infection and severe COVID-19 in MM and MGUS relative to matched controls.