Survival and biological effects. (A) Progression-free survival and overall survival in the 20 patients treated with anakinra with axi-cel. (B) CAR T-cell amplification in peripheral blood compared with a contemporaneous matched cohort as measured by quantitative polymerase chain reaction; VCN, vector copy number. (C) Heatmap of inflammatory markers in the plasma of patients treated with anakinra compared with a contemporaneous matched cohort receiving axi-cel only. For CAR T-cell amplification, comparisons between cohorts was performed using Mann-Whitney U test: ∗∗ P < .01; ∗∗∗ P < .001. Median values are displayed with error bars showing interquartile range. In the heatmap, data for median plasma levels of each cytokine are represented by the same scale for both cohorts.