Figure 7.
The developing thymus recovers rapidly after exposure to DHODH inhibition. T-cell populations were quantified by flow cytometric analysis. T cells were isolated from the thymi of juvenile mice treated with vehicle (VEH) or BRQ 50 mg/kg every 3 days for 2 doses, followed by a 2-week or a 4-week recovery period. Shown are double-negative (DN) as well as DN1-4 subgroups, single positive (CD4+ and CD8+), and double-positive (DP) groups. n = 3 mice for each interval time point analysis. ns, not significant.

The developing thymus recovers rapidly after exposure to DHODH inhibition. T-cell populations were quantified by flow cytometric analysis. T cells were isolated from the thymi of juvenile mice treated with vehicle (VEH) or BRQ 50 mg/kg every 3 days for 2 doses, followed by a 2-week or a 4-week recovery period. Shown are double-negative (DN) as well as DN1-4 subgroups, single positive (CD4+ and CD8+), and double-positive (DP) groups. n = 3 mice for each interval time point analysis. ns, not significant.

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