TTNT after first-line systemic therapies. (A) TTNT after first-line combination therapies vs first-line monotherapies. Patients receiving first-line combination therapy had significantly longer TTNT (median TTNT, 10.0 vs 5.0 months; P = .004). (B) TTNT after first-line ECP-containing treatment vs first-line non-ECP–containing treatments. Patients receiving ECP-containing therapy had significantly longer TTNT (median TTNT, 9.0 vs 4.9 months; P = .007).