Figure 2.
Genetic dependency on BCL2L1 in erythroid and megakaryoblastic leukemias. (A) Volcano plot of the most essential genes in erythroid compared with other AML cell lines in genome-scale CRISPR-Cas9 screening data from DepMap. Genes with a nominal P value < .05 and absolute values of differential gene effect >0.6 are colored in red or blue. In addition, the BCL-2 family members BCL2 and MCL1 are colored in blue. Fifteen percent FDR is indicated with a dashed line. (B) BCL2L1 CRISPR gene knockout effect in AML cell lines. More negative values indicate stronger dependency. (C) Volcano plot of most essential genes in erythroid/megakaryoblastic AML cell lines compared with other AML cell lines in RNAi screening data from the Achilles project. Genes with a nominal P value < .05 and absolute values of differential gene effect >0.5 are colored in red or blue. In addition, the BCL-2 family members BCL2 and MCL1 are colored in blue. Fifteen percent FDR is indicated with a dashed line. (D) BCL2L1 RNAi dependency score in AML cell lines. More negative values indicate stronger dependency. FDR, false discovery rate.

Genetic dependency on BCL2L1 in erythroid and megakaryoblastic leukemias. (A) Volcano plot of the most essential genes in erythroid compared with other AML cell lines in genome-scale CRISPR-Cas9 screening data from DepMap. Genes with a nominal P value < .05 and absolute values of differential gene effect >0.6 are colored in red or blue. In addition, the BCL-2 family members BCL2 and MCL1 are colored in blue. Fifteen percent FDR is indicated with a dashed line. (B) BCL2L1 CRISPR gene knockout effect in AML cell lines. More negative values indicate stronger dependency. (C) Volcano plot of most essential genes in erythroid/megakaryoblastic AML cell lines compared with other AML cell lines in RNAi screening data from the Achilles project. Genes with a nominal P value < .05 and absolute values of differential gene effect >0.5 are colored in red or blue. In addition, the BCL-2 family members BCL2 and MCL1 are colored in blue. Fifteen percent FDR is indicated with a dashed line. (D) BCL2L1 RNAi dependency score in AML cell lines. More negative values indicate stronger dependency. FDR, false discovery rate.

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal