Patients with 8-OHdG^hiT cells with a higher incidence of relapse and a shorter OS. (A-B) Kaplan-Meier analysis of relapse incidence and OS of patients who underwent allo-SCT with respect to the 8-OHdG level in CD3⁺ T cells. 8-OHdG categorization is based on the mean 8-OHdG MFI of all investigated time points after allo-SCT. Patients who underwent 8-OHdG^hi allo-SCT (n = 22) represent the top 33%, and those who underwent 8-OHdG^lo allo-SCT (n = 22) the lowest 33% of the cohort. (C) ROC analyses were performed for relapse and OS for all patients who underwent allo-SCT (n = 66). The AUC was calculated separately for 8-OHdG expression in CD3⁺ T cells on days +30, +45, +60, +75, +90, and +120 after allo-SCT. (D-E) Kaplan-Meier analysis of relapse incidence and OS of patients who underwent allo-SCT with respect to the 8-OHdG level in CD3⁺ T cells at d +60 after allo-SCT. Patients who underwent 8-OHdG^hi allo-SCT (n = 34) represent the top 33%, and those who underwent 8-OHdG^lo allo-SCT (n = 33) represent the lowest 33% of an expanded patient cohort. AUC, area under the curve.