Figure 4.
Analysis of FIX-WT and FIX variant activities in HB mice 10 minutes after FIX injection. (A) FIX activity levels based on 1-stage aPTT FIX-specific clotting in plasma from HB mice injected with FIX proteins (250 μg/kg). Data are presented as the mean ± SD from n = 3 to 4 per group. (B) Representative ROTEM traces in whole blood obtained from HB mice that received FIX protein (125 μg/kg). Controls: WT mice (dark gray) and HB mice (gray). (C) ROTEM clot times after the administration of FIX proteins at the indicated doses in HB mice. Data are presented as mean ± SD from n = 2 to 5 per group. Adjusted P values were obtained using an analysis of variance (ANOVA) test followed by a Tukey test. ∗∗P < .001 or not significant (n.s.) represent FIX variants vs FIX-WT infused animals.

Analysis of FIX-WT and FIX variant activities in HB mice 10 minutes after FIX injection. (A) FIX activity levels based on 1-stage aPTT FIX-specific clotting in plasma from HB mice injected with FIX proteins (250 μg/kg). Data are presented as the mean ± SD from n = 3 to 4 per group. (B) Representative ROTEM traces in whole blood obtained from HB mice that received FIX protein (125 μg/kg). Controls: WT mice (dark gray) and HB mice (gray). (C) ROTEM clot times after the administration of FIX proteins at the indicated doses in HB mice. Data are presented as mean ± SD from n = 2 to 5 per group. Adjusted P values were obtained using an analysis of variance (ANOVA) test followed by a Tukey test. ∗∗P < .001 or not significant (n.s.) represent FIX variants vs FIX-WT infused animals.

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