Figure 5.
Young gut microbiota reduced inflammation and protected intestinal barriers in aged mice. (A) Representative images showing the intestinal length of FMT-YA and FMT-AA mice. (B) Bar graphs showing the intestinal lengths of FMT-YA and FMT-AA mice. (C) Representative images showing the number of goblet cells by Acian Blue PAS staining. Scale bars, 20 μm. (D) Bar graphs showing the number of goblet cells from FMT-YA and FMT-AA mice. (E) The intestinal permeability of FMT-YA and FMT-AA mice measured by fluorescein isothiocyanate (FITC)–dextran in blood. Data were normalized to aged FMT-AA controls. (F-H) The expression of interferon gamma (IFN-γ), IL-6, and IL-4 in intestinal tissue by quantitative reverse transcription polymerase chain reaction. Graphs show mean ± SEM, with statistical significance determined by Student t test (n = 6 per group). ∗P < .05, ∗∗P < .01. mRNA, messenger RNA.

Young gut microbiota reduced inflammation and protected intestinal barriers in aged mice. (A) Representative images showing the intestinal length of FMT-YA and FMT-AA mice. (B) Bar graphs showing the intestinal lengths of FMT-YA and FMT-AA mice. (C) Representative images showing the number of goblet cells by Acian Blue PAS staining. Scale bars, 20 μm. (D) Bar graphs showing the number of goblet cells from FMT-YA and FMT-AA mice. (E) The intestinal permeability of FMT-YA and FMT-AA mice measured by fluorescein isothiocyanate (FITC)–dextran in blood. Data were normalized to aged FMT-AA controls. (F-H) The expression of interferon gamma (IFN-γ), IL-6, and IL-4 in intestinal tissue by quantitative reverse transcription polymerase chain reaction. Graphs show mean ± SEM, with statistical significance determined by Student t test (n = 6 per group). ∗P < .05, ∗∗P < .01. mRNA, messenger RNA.

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