SCD affects morphology of venous clots. Representative, hematoxylin and eosin–stained images of femoral vein clots harvested from HbAA and HbSS mice 1 hour after electrolytic injury, (original magnification ×4). In the clots, areas rich in RBCs stain dark red whereas areas of fibrin and platelets stain light pink. In the enlarged images on the right, asterisks denote acellular empty spaces within the clots; dark blue staining denotes inflammatory cells within the clots.