Figure 2.
Nonhematopoietic FXII contributes to increased thrombin generation and inflammation in HbSS mice at steady state and after TNFα challenge. FXII−/− and FXII+/+ mice were irradiated and received transplantation with HbAA or HbSS BM. Four months later, plasma was collected for analysis of (A) TAT complexes, (B) IL-6, and (C) sVCAM-1. In a separate study, all mice were treated with TNFα (2 μg/kg, intraperitoneally). Five hours later, plasma was collected for analysis of (D) TAT complexes, (E) IL-6, and (F) sVCAM-1. Data are represented as mean ± SEM, n = 10 to 26 per group. ∗P < .05, ∗∗P < .01, and ∗∗∗∗P < .0001 by two-way analysis of variance (ANOVA) and Tukey post-hoc test. Asterisks above bars indicate significance within the same FXII genotype. Asterisks above lines indicate difference between Hb genotype within FXII genotype.

Nonhematopoietic FXII contributes to increased thrombin generation and inflammation in HbSS mice at steady state and after TNFα challenge. FXII−/− and FXII+/+ mice were irradiated and received transplantation with HbAA or HbSS BM. Four months later, plasma was collected for analysis of (A) TAT complexes, (B) IL-6, and (C) sVCAM-1. In a separate study, all mice were treated with TNFα (2 μg/kg, intraperitoneally). Five hours later, plasma was collected for analysis of (D) TAT complexes, (E) IL-6, and (F) sVCAM-1. Data are represented as mean ± SEM, n = 10 to 26 per group. ∗P < .05, ∗∗P < .01, and ∗∗∗∗P < .0001 by two-way analysis of variance (ANOVA) and Tukey post-hoc test. Asterisks above bars indicate significance within the same FXII genotype. Asterisks above lines indicate difference between Hb genotype within FXII genotype.

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