Myeloid gene comutations in t-NPM1 AML. 107 cases of t-NPM1 AML (columns) were subjected to targeted sequencing of genes recurrently mutated in myeloid neoplasms, which are shown in rows when mutated in at least 1 case. Above the gene mutation grid, each case is also annotated with karyotype, FLT3-ITD status as assessed by fragment length analysis, and inclusion in the clinical cohort. Color-coded figure keys are shown below the grid (regarding karyotype, cases denoted with “other” have chromosomal abnormalities other than those listed in Table 2).