Glycolysis and mitochondrial OXPHOS in AML and relevant therapeutic strategies. Schematic representation showing the cellular uptake and downstream utilization of glucose and fructose. Enzymes with demonstrated relevance to AML pathophysiology are highlighted in blue. Chemical and biological inhibitors are highlighted in red. Biological outputs and metabolic pathways are highlighted in pink. 2,5-AM, 2,5-anhydro-D-mannitol; FK, fructose kinase; LDH, lactate dehydrogenase; MCTs, monocarboxylate transporters; PEP, phosphoenolpyruvate.