FA metabolism in AML and relevant therapeutic strategies. Schematic representation showing the transport of citrate into the cytoplasm, conversion to acetyl-CoA, and generation of FA intermediates through either downstream carboxylation or alternatively through the MVA pathway. Enzymes with demonstrated relevance to AML pathophysiology are highlighted in blue. Chemical inhibitors or gene silencing effects are highlighted in red. ACC, acetyl Co-A carboxylase; ACLY, ATP citrate lyase; DCV, dehydrocurvularin; FASN, fatty acid synthase; HMGCR, HMG-CoA reductase; ME1, malic enzyme 1; OAA, oxaloacetate; SCD1, stearoyl CoA desaturase 1.