Effects of rondaptivon pegol on FVIII activity levels in nonsevere hemophilia. Effects of the VWF-binding aptamer rondaptivon pegol on FVIII activity levels in 8 patients with mild (blue lines) and 2 patients with moderate (red lines) hemophilia A. Data for patients with mild hemophilia are additionally summarized as median (blue diamonds) with interquartile range (error bars). Contrast test: P < .0001.