Analysis of “heptad” TF binding and chromatin interactions identifies a connectivity map of known and novel putative CREs in CD34⁺ mobilized HSC-MPP (hematopoietic stem cells and multipotential progenitor), CMP (common myeloid progenitor), GMP (granulocytic and macrophage progenitor), and MEP (megakaryocyte-erythroid progenitor) populations. 1 and 2 symbolically indicate heptad-bound CIS regulatory elements (CREs) associated with select lineage-specific gene expression in GMPs and MEPs, respectively. Professional illustration by Somersault18:24.