Kaplan-Meier analyses of TTST in skin-limited MF and representative plots of the frequency of productive TCRβ CDR3 rearrangements in the blood and skin. Kaplan-Meier analyses of TTST in patients with skin-limited MF (A) with and without a dominant T-cell clone in blood, (B) with an identical dominant T-cell clone in the blood and skin, a discordant dominant T-cell clone in blood and skin, and no dominant blood clones. (C-F) Representative plots of patients’ data depicting the frequency of all TCRβ CDR3 productive sequences either unique to the skin (blue) or blood (red) or shared between blood and skin (purple) in patients with skin-limited MF (C-D) with discordant dominant T-cell clones in the blood and skin, (E) with a dominant clone in the skin but no dominant clone in the blood, and (F) with an identical dominant T-cell clone in the blood and skin. The total numbers of CDR3 sequences for each plot of panel C: 890 (22%), skin; 3121 (77%), blood; and 50 (1%) shared; panel D: 1104 (10%), skin; 9474 (88%), blood; and 227 (2%), shared; panel E: 1515 (13%), skin; 9957 (85%), blood; and 307 (2%) shared; and panel F: 2183 (48%), skin; 2301 (51%), blood; 52 (1%), shared. ∗∗P = .0057; ∗∗∗P < .0003. NS, not significant, P = .5274.