PCA of microspots and hematologic traits of patients and controls. For all included patients, family members, and controls (CCFs and CCBs), multiparameter data (P1-8) of thrombus formation on microspots from M1 to M6 together with hematologic values, were univariately scaled and clustered for PCA using scaled and mean-centered data (k-means = 3). Missing values were imputed. (A) Default 2-component plot resulting in clusters of (1) controls and most carriers of a heterozygous mutation; (2) most of index patients and autosomal recessive compound heterozygous carriers; (3) family members from Pat 09 to Pat11 with SPD and moderate TCP. (B) Euclidean distance matrix of clustered scaled parameters comparing all individual patients. For values, see supplemental Datafile.