JQ1 and JQ5 impair the GC reaction in murine cGVHD/BO mice. (G) Flow cytometric analysis of single-cell lung suspensions taken from transplanted mice treated with each drug (n = 5/group). (Left) Total plasma cells are CD138⁺ lymphocytes, (center) immature plasma cells are B220⁺, CD19⁺ plasma cells, and (right) mature plasma cells are B220⁻, CD19⁻ plasma cells. Results show that both drugs significantly reduced the proportion of mature plasma cells in subject lungs.