MYD88^L265P expression increases the colocalization of MYD88 with DOCK8 and DOCK8 with LYN in DLBCL. (A) (Top) Confocal images of MYD88:DOCK8 PLA signals in DHL4, LY1, and LY7 parental (p), MYD88^WT (W)-, or MYD88^L265P (M)-overexpressing cells. (Bottom) Quantification of PLA signals in n > 60 cells classified per condition. Violin plots, ∗∗P < .01; ∗∗∗∗P < .0001. (B) (Top) Confocal images of LYN:DOCK8 PLA signals in DHL4, LY1, and LY7 p, W-, or M-overexpressing cells. (Bottom) Quantification data of n > 40 cells classified per condition. Violin plots, ∗P < .05; ∗∗∗P < .001; ∗∗∗∗P < .0001. Asterisks represent P values in a Mann-Whitney test.