ML355 and AA binding sites in the 12-LOX hexamer. (A) Model of the 12-LOX hexamer with density at the catalytic site shown in gray. The graphical representation is shown in the bottom left corner. (B) Density of AA and ML355. Density is shown as a transparent surface, and the models as sticks (orange for ML355 and pink for AA) colored by heteroatoms. (C) Model of 12-LOX bound to ML355 and AA. (D-E) 12-LOX residues in contact with (D) ML355 (orange) and (E) AA (pink) are shown as sticks. Iron atom is shown as a red sphere.