Oligomeric structures of 12-LOX. Models of 12-LOX as (A) monomer, (B) dimer, (C) tetramer, and (D) hexamer. Each subunit is represented by a different color and the α2-helix colored in pink and an arched helix in cyan. The graphical representation of each oligomeric state at the bottom left and inset details the oligomeric interface. Interacting amino acids are shown as sticks. (D) Cys89 (red) contributes a disulfide bridge to the interface of the hexamer. The Fe atom is shown as a red sphere.