Different oligomeric forms of 12-LOX. (A) SEC UV absorbance trace (280 nm ) of 12-LOX purification. 12-LOX separated as 2 distinct peaks, 1 corresponding to a tetramer (red box) and the other corresponding to a dimer (blue box). (B) Cryo-EM map of a 12-LOX tetramer from tetrameric SEC peak. (C) Cryo-EM maps of different 12-LOX oligomers resolved from dimeric SEC peak.