Single-cell multiomics study in BMF syndrome. By starting with just a few cells, single-cell multiomics studies can yield a wealth of information on various aspects of BMF syndrome diseases and treatment: vast data sets, cell clusters, hematopoietic differentiation trajectory, chromosomal abnormalities, gene mutations, gene splicing, DNA methylation, TCR/B-cell receptor (BCR) variable diversity joining (VDJ) gene usage, and cell–cell interactions. Figure created with BioRender.com.