Adaptive and cytokine-induced memory-like NK cells. Adaptive and cytokine-induced memory-like NK cells are distinct memory NK cell types. Adaptive NK cells are induced after viral infection and demonstrate enhanced responses to antibody-mediated activation, and they proliferate robustly after subsequent virus exposure. Memory-like NK cells are induced through IL-12, IL-15, IL-18 and with the addition of CD16 engagement. Memory-like NK cells demonstrate enhanced cytokine production and killing in response to multiple stimuli, including Fc-receptor ligation, activating receptor ligation, and cytokine receptor activation.