Figure 2.
Constitutively expressed cytokine receptors on NK cells. Common gamma chain (γc) receptors constitutively expressed by NK cells include intermediate affinity IL-2/IL-15 (βγc) receptor. High-affinity IL-15Rα is presented in trans by other cell types. CD56bright NK cell subsets constitutively express high-affinity IL-2Rα and IL-7R, CD56dim NK cells upregulate these receptors upon activation. IL-12R is constitutively expressed and required for adaptive memory responses. TGFβR inhibits IL-15R signal transduction and significantly alters NK cell phenotype and effector functions.

Constitutively expressed cytokine receptors on NK cells. Common gamma chain (γc) receptors constitutively expressed by NK cells include intermediate affinity IL-2/IL-15 (βγc) receptor. High-affinity IL-15Rα is presented in trans by other cell types. CD56bright NK cell subsets constitutively express high-affinity IL-2Rα and IL-7R, CD56dim NK cells upregulate these receptors upon activation. IL-12R is constitutively expressed and required for adaptive memory responses. TGFβR inhibits IL-15R signal transduction and significantly alters NK cell phenotype and effector functions.

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