Kaplan-Meier survival curves and log-rank P values in the focused cohort at baseline by risk group. (A) PFS (B) OS is worse in the high-risk group (high MTV/high ctDNA) compared with the intermediate-risk (high MTV/low ctDNA or low MTV/high ctDNA) or low-risk (low MTV/low ctDNA) groups. MTV cutoff was >147.5 mL and ctDNA cutoff was >100 Lg/mL.