High number of intratumoral T_reg cells correlates with high numbers of CD70⁺ cells in SOX11⁺ nodal MCLs, and it is associated with shorter OS of MCL patients. (D-E) Positive correlation between CD70⁺ cells and FOXP3⁺/CD4⁺ T-cell ratio (D) and CD70⁺ cells and (FOXP3⁺CTLA4⁺)/CD4⁺ T-cell ratio (E) in SOX11⁺ (red) and SOX11⁻ (blue) nodal MCLs, quantified by IHC in our series of nodal MCLs. Graphs show Pearson correlation coefficient (r), P value, and number of cases analyzed (N).