Effect of treatment with saline, or control, HRG, or FXII ASOs on time to catheter occlusion and thrombus weight. After a 4-week course of treatment with saline (n = 6 per group), or control, HRG, or FXII ASOs (n = 8 per group), catheters were implanted in the jugular vein and the time to catheter occlusion (A) and the weight of the explanted catheter thrombi (B) were determined. Mean ± SD, with the symbols representing the results in individual rabbits. ^∗P < .05; ^∗∗P < .01; ^∗∗∗P < .001; and ^∗∗∗∗P < .0001 comparisons between catheter occlusion times or thrombus weights as indicated by the lines; (one-way ANOVA and Holm-Sidak method). (C) Representative images of explanted catheters with intralumenal thrombi. NS, not significant.