Effect of treatment with saline, or control, HRG, or FXII ASOs on the aPTT and PT. The dilute aPTT (red bars) and PT (blue bars) were determined in the plasma collected from rabbits after a 4-week course of treatment with saline (n = 6) or control, or HRG or FXII ASO (N = 8 per group). Bars represent mean ± SD from 3 determinations for each rabbit. ^∗P < .05; ^∗∗P < .01; and ^∗∗∗P < .001 comparison of aPTT results as indicated by the lines (one-way ANOVA and Holm-Sidak method).