Host responses to infection with P falciparum in late erythroblasts. (A) Enrichment analysis results using MSigDB Hallmark gene sets with DEGs (infected vs uninfected) detected in PolyE and OrthoE populations. Analysis of DEGs with log fold change > 0 (UP), and analysis of DEGs with log fold change < 0 (DOWN) are shown. Size indicates significance. Color indicates the odds ratio based on a Fisher exact test. (B-C) Expression of stress-related genes in PolyE and OrthoE populations. (D) Expression of MXI1, an enucleation factor, in PolyEs and OrthoEs. (E) Expression of FECH, encoding protoporphyrin ferrochetalase, in PolyEs and OrthoEs. Data are shown as median with 95% confidence intervals.