Biomarker and blood cell levels in a mouse xenograft model of APL. (A) TAT, (B) fibrinogen, (C) D-dimer, (D) PAP, (E) sE-selectin, (F) sP-selectin, (G) platelet count, (H) MPV, (I) WBC count, (J) RBC count, and (K) hemoglobin (Hgb) levels were measured in the plasma or whole blood of control and leukemic mice on days 14, 21, 24, and 28 (n = 4-6 per group). Data are shown as mean ± SD (A-C,E,G-K) or median ± interquartile range (D,F), depending on normality. The one-way analysis of variance with Dunnett multiple comparisons test (A-C,E,G-K) or the Kruskal-Wallis test with Dunn multiple comparisons test (D,F) was used, depending on the normality of data. ∗P < .05; ∗∗P < .01; ∗∗∗∗P < .0001.