The DR score is dynamic within an individual tumor, its level at the time of CAR T-cell treatment correlates with overall survival and tumor response. (A) DR score was compared between sham (0 Gy) and low-dose radiation (1.8 Gy) 7 days after the treatment. (B) heatmap of individual samples (columns) and genes (rows) comprising the DR score. (C) Mice injected with Nalm6 tumor cells were treated with low-dose RT on day 3 followed by low-dose CAR T cells either 1 or 7 days later, corresponding with the timepoints of RNA-seq from Figures 5A and 6A. Overall survival (C) and tumor burden (D) of mice in the indicated treatment group shown over time.