Interplay of clonal hematopoiesis, systemic inflammation, and IL-6R p.D358A. (A) IL-6 levels according to the IL-6R p.D358 variant. (B) hsCRP levels according to the IL-6R p.D358 variant. (C) Kaplan-Meier analysis of the CEP, stratified by CH status and IL-6R p.D358 variant. (D) Kaplan-Meier analysis of the CEP, stratified by TET2 mutation (mut.) status and IL-6R p.D358 variant. (E) HRs and 95% CI for the CEP from univariable Cox regression for CH-positive (pos.) patients, according to the IL-6R p.D358 variant compared with CH-negative (neg.) patients. (F) HRs and 95% CI for the CEP from univariable Cox regression for TET2-mutated patients, according to the IL-6R p.D358 variant compared with CH-negative patients. WT, wild type.