Analysis of inflammatory biomarkers and white matter lesion load. (A) Boxplots of levels of inflammatory biomarkers at baseline of 562 patients with respect to CH mutation status as well as fraction of patients with IFN-γ values ≥ detection limit (3.20 pg/mL). (B) Boxplots of IL-1β levels in patients with a single TET2 mutation compared with CH-negative patients. (C) White matter lesion load in 398 patients with available MRI data, measured by the Wahlund score according to CH status. P values above brackets from Wilcoxon rank-sum test.