Figure 4.
SR604 significantly improves survival and ameliorates inflammation of knee-joint injury of humanized hemophilic mice. (A) Survival rates after injuries. (B) The change of the knee-joint diameter of mice calculated as percentage of the value before injury. Knee diameters were measured with an electronic caliper before needle injury and every other day after the injury; n = 6 mice per group. ∗∗P < .01. (C) Microscopic images of hematoxylin and eosin–stained knee joint tissues (original magnification ×20). Marked areas show inflammation and proliferation of the synovial and stromal linings. Bar graph represents quantification of the thickness of the inflamed and proliferated synovial and stromal linings; n = 3 mice per group. ∗P < .05; ∗∗∗P < .001.

SR604 significantly improves survival and ameliorates inflammation of knee-joint injury of humanized hemophilic mice. (A) Survival rates after injuries. (B) The change of the knee-joint diameter of mice calculated as percentage of the value before injury. Knee diameters were measured with an electronic caliper before needle injury and every other day after the injury; n = 6 mice per group. ∗∗P < .01. (C) Microscopic images of hematoxylin and eosin–stained knee joint tissues (original magnification ×20). Marked areas show inflammation and proliferation of the synovial and stromal linings. Bar graph represents quantification of the thickness of the inflamed and proliferated synovial and stromal linings; n = 3 mice per group. ∗P < .05; ∗∗∗P < .001.

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