Figure 4.
Swimmer’s plot for post-ASCT plasma MRD samples. In this swimmer’s plot, orange bars represent relapsed patients and a black X marks the time of relapse. An asterisk next to black X indicates a patient who relapsed with indolent lymphoma. Gray bars indicate patients in remission. The blue triangle marks the timing of ASCT. Red circles indicate positive MRD samples (with the size of the circle corresponding to the quantity of detectable ctDNA). Blue circles represent the MRD-negative samples. A red X indicates death without lymphoma relapse. Patients are grouped according to relapse status and MRD detection. The first group of patients (“true positives”) had MRD detected before or at the time of relapse. The second group of patients (“true negatives”) are patients in remission with only negative MRD assessments. The third group of patients (“false negatives”) relapsed without detectable MRD. (Note: most of these patients did not have a plasma sample available for testing in close proximity to clinical relapse). The fourth group of patients (“false positives”) are in remission, but each had 1 positive MRD assessment. The final group of patients died without any evidence of lymphoma relapses.

Swimmer’s plot for post-ASCT plasma MRD samples. In this swimmer’s plot, orange bars represent relapsed patients and a black X marks the time of relapse. An asterisk next to black X indicates a patient who relapsed with indolent lymphoma. Gray bars indicate patients in remission. The blue triangle marks the timing of ASCT. Red circles indicate positive MRD samples (with the size of the circle corresponding to the quantity of detectable ctDNA). Blue circles represent the MRD-negative samples. A red X indicates death without lymphoma relapse. Patients are grouped according to relapse status and MRD detection. The first group of patients (“true positives”) had MRD detected before or at the time of relapse. The second group of patients (“true negatives”) are patients in remission with only negative MRD assessments. The third group of patients (“false negatives”) relapsed without detectable MRD. (Note: most of these patients did not have a plasma sample available for testing in close proximity to clinical relapse). The fourth group of patients (“false positives”) are in remission, but each had 1 positive MRD assessment. The final group of patients died without any evidence of lymphoma relapses.

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