PRS analysis for proteinuria using summary statistics from the CKDGen Consortium UACR GWAS. (A) Forest plot depicting the FE proteinuria meta-analysis of OMG-SCD and Walk-PHaSST generated using metafor at the maximizing P value threshold (P_T) = .05. (B) Bar plot depicting model fit (R²) of the CKDGen Consortium UACR PRS predicting proteinuria in OMG-SCD at a wide range of P value thresholds. (C) Bar plot depicting model fit (R²) of the CKDGen Consortium UACR PRS predicting proteinuria in Walk-PHaSST at a wide range of P value thresholds. Model fit for proteinuria (depicted in B-C) was estimated using Nagelkerke pseudo R². FE, fixed effects.