Patient’s distribution based on WHO 2016, ICC, and WHO 2022 diagnostic classifications. (A) Distribution of 1001 patients with AML based on the diverse classifications. (B) Relationship, overlaps, and differences across different AML subtypes shown using a Sankey plot. The overall proportion of genetically defined AML, based on the new classifications, is shown in brackets. APL, acute promyelocytic leukemia; MECOM-R, MECOM rearrangements; MECOM-RE, MECOM with extended rearrangements; KMT2A-R, KMT2A rearrangements; KMT2A-RE, KMT2A with extended rearrangements; MPN, myeloproliferative neoplasm; MR, myelodysplasia-related; MRC, myelodysplasia-related changes.