The percentage of PLEKHM1⁺ MSCs may be reduced in bone sections of human patients with B-ALL compared to CML. (A) Representative bone sections of a healthy individual and human patients with B-ALL, CML, AML, or multiple myeloma (MM). The bone sections are stained with antibodies to CD271 (pink), labeling mesenchymal stroma cells, and PLEKHM1 (brown). The scale bar represents 200 μm. (B) Percentage of PLEKHM1⁺ CD271⁺ cells of all CD271⁺ cells in bone sections of healthy individuals (n = 5) or patients with B-ALL (n = 5), CML (n = 5), AML (n = 4) or MM (n = 4) (one-way ANOVA, Tukey multiple comparisons test). The exact genotypes of the different leukemias are unknown.