Color-coded mutation profiles for each of the 14 genomic clusters, determined using a uniform manifold approximation of projection (UMAP) technique, which reduces the 16-dimensional binary mutation profiles into a three-dimensional (3D) diagram. Each cluster occupies a distinct space on the 3D diagram, indicating a unique mutation signature (adapted from Figure 1B in Kewan, T et al. Nat Comm. 2023;14:3136).